Strange murders and cases of canabalsm have been occurring in the Alklay Mountains of Raccoon City. The Raccoon City Police Department send in S.T.A.R.S. (Special Tactics And Rescue Services) to investigate. S.T.A.R.S. members are dropped off in the woods by Brad Vickers. The team is attacked by ravenous dogs and loose contact with the helicopter, and the chopper flies away. The team is split up, and their captain, Wesker, is devoured by dogs. Chris Redfeild, Jill Valentine, and some other guy find a mansion in the woods. They enter it and believe other members may have ran in too. They decide to search for survivors. They end up finding that this mansion is home to Umbrella Corporation's evil experiments when they find a zombie tearing the head off of a S.T.A.R.S. member. The rest of the Shame then involves you solving puzzles and killing zombies. In the end, the survivors are rescued and flown back to Raccoon City. They are safe, but for how long?
For further reading, see Resident Evil 2